Postsynaptic alteration of NR2A subunit and defective autophosphorylation of alphaCaMKII at threonine-286 contribute to abnormal plasticity and morphology of upper motor neurons in presymptomatic SOD1G93A mice, a murine model for amyotrophic lateral sclerosis.

Spalloni, A; Origlia, N; Sgobio, C; Trabalza, A; Nutini, M; Berretta, N; Bernardi, G; Domenici, L; Ammassari-Teule, M; Longone, P

Spalloni, A; Origlia, N; Sgobio, C; Trabalza, A; Nutini, M; Berretta, N; Bernardi, G; Domenici, L; Ammassari-Teule, M; Longone, P.

Affiliation

Spalloni A; Department of Experimental Neurology, Santa Lucia Foundation, 00143 Rome, Italy.

Cereb Cortex ; 21(4): 796-805, 2011 Apr.

Article in En | MEDLINE | ID: mdl-20732897

Subject(s)

Amyotrophic Lateral Sclerosis/physiopathology; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism; Motor Neurons/metabolism; Neuronal Plasticity/physiology; Receptors, N-Methyl-D-Aspartate/biosynthesis; Amyotrophic Lateral Sclerosis/metabolism; Amyotrophic Lateral Sclerosis/pathology; Animals; Blotting, Western; Disease Models, Animal; Evoked Potentials; Fluorescent Antibody Technique; Humans; Mice; Mice, Transgenic; Microscopy, Confocal; Motor Neurons/pathology; Mutation; Phosphorylation; Superoxide Dismutase/genetics; Superoxide Dismutase-1; Threonine/metabolism

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Full text: 1 Database: MEDLINE Main subject: Receptors, N-Methyl-D-Aspartate / Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Amyotrophic Lateral Sclerosis / Motor Neurons / Neuronal Plasticity Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cereb Cortex Journal subject: CEREBRO Year: 2011 Type: Article Affiliation country: Italy

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