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Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: gradual release enhances activity.
Breitbach, Anthony S; Broderick, Adam H; Jewell, Christopher M; Gunasekaran, Suvai; Lin, Qi; Lynn, David M; Blackwell, Helen E.
Affiliation
  • Breitbach AS; Department of Chemistry, University of Wisconsin-Madison, 1101 University Ave., Madison, WI 53706, USA.
Chem Commun (Camb) ; 47(1): 370-2, 2011 Jan 07.
Article in En | MEDLINE | ID: mdl-20830354
ABSTRACT
We demonstrate an approach to the surface-mediated release of a synthetic N-acylated L-homoserine lactone (AHL) modulator of bacterial quorum sensing (QS). AHL released gradually from thin films of poly(lactide-co-glycolide) (PLG) is shown to activate QS in the model symbiont Vibrio fischeri at levels that exceed those promoted by direct solution-based administration.
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Full text: 1 Database: MEDLINE Main subject: 4-Butyrolactone / Aliivibrio fischeri / Quorum Sensing Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2011 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: 4-Butyrolactone / Aliivibrio fischeri / Quorum Sensing Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2011 Type: Article Affiliation country: United States