Raised hepatic bile acid concentrations during pregnancy in mice are associated with reduced farnesoid X receptor function.

Milona, Alexandra; Owen, Bryn M; Cobbold, Jeremy F L; Willemsen, Ellen C L; Cox, Isobel J; Boudjelal, Mohamed; Cairns, William; Schoonjans, Kristina; Taylor-Robinson, Simon D; Klomp, Leo W J; Parker, Malcolm G; White, Roger; van Mil, Saskia W C; Williamson, Catherine

Milona, Alexandra; Owen, Bryn M; Cobbold, Jeremy F L; Willemsen, Ellen C L; Cox, Isobel J; Boudjelal, Mohamed; Cairns, William; Schoonjans, Kristina; Taylor-Robinson, Simon D; Klomp, Leo W J; Parker, Malcolm G; White, Roger; van Mil, Saskia W C; Williamson, Catherine.

Affiliation

Milona A; Department of Surgery and Cancer, Institute of Reproductive and Developmental Biology, London, United Kingdom.

Hepatology ; 52(4): 1341-9, 2010 Oct.

Article in En | MEDLINE | ID: mdl-20842631

Subject(s)

Bile Acids and Salts/metabolism; Liver/metabolism; Pregnancy, Animal/physiology; Receptors, Cytoplasmic and Nuclear/physiology; Animals; Estradiol/analogs & derivatives; Estradiol/pharmacology; Estrogen Receptor alpha/antagonists & inhibitors; Estrogen Receptor alpha/metabolism; Female; Fulvestrant; Gene Expression Profiling; Humans; Mice; Mice, Inbred C57BL; Pregnancy; Pregnancy, Animal/blood; RNA, Messenger/metabolism; Receptors, Cytoplasmic and Nuclear/biosynthesis

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Full text: 1 Database: MEDLINE Main subject: Pregnancy, Animal / Bile Acids and Salts / Receptors, Cytoplasmic and Nuclear / Liver Type of study: Risk_factors_studies Limits: Animals / Female / Humans / Pregnancy Language: En Journal: Hepatology Year: 2010 Type: Article Affiliation country: United kingdom

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