Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies.

Gong, Yan; Bourhis, Eric; Chiu, Cecilia; Stawicki, Scott; DeAlmeida, Venita I; Liu, Bob Y; Phamluong, Khanhky; Cao, Tim C; Carano, Richard A D; Ernst, James A; Solloway, Mark; Rubinfeld, Bonnee; Hannoush, Rami N; Wu, Yan; Polakis, Paul; Costa, Mike

Gong, Yan; Bourhis, Eric; Chiu, Cecilia; Stawicki, Scott; DeAlmeida, Venita I; Liu, Bob Y; Phamluong, Khanhky; Cao, Tim C; Carano, Richard A D; Ernst, James A; Solloway, Mark; Rubinfeld, Bonnee; Hannoush, Rami N; Wu, Yan; Polakis, Paul; Costa, Mike.

Affiliation

Gong Y; Department of Cancer Targets, Genentech Research & Early Development, South San Francisco, California, United States of America.

PLoS One ; 5(9): e12682, 2010 Sep 13.

Article in En | MEDLINE | ID: mdl-20856934

Subject(s)

Antibodies/pharmacology; Down-Regulation/drug effects; LDL-Receptor Related Proteins/immunology; Receptors, G-Protein-Coupled/metabolism; Signal Transduction/drug effects; Wnt Proteins/metabolism; Animals; Cell Line; Humans; LDL-Receptor Related Proteins/genetics; LDL-Receptor Related Proteins/metabolism; Low Density Lipoprotein Receptor-Related Protein-6; Mice; Protein Binding/drug effects; Protein Isoforms/genetics; Protein Isoforms/metabolism; Receptors, G-Protein-Coupled/genetics; Species Specificity; Up-Regulation/drug effects; Wnt Proteins/genetics

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Full text: 1 Database: MEDLINE Main subject: Signal Transduction / Down-Regulation / LDL-Receptor Related Proteins / Receptors, G-Protein-Coupled / Wnt Proteins / Antibodies Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2010 Type: Article Affiliation country: United States

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