Definition of ubiquitination modulator COP1 as a novel therapeutic target in human hepatocellular carcinoma.

Lee, Yun-Han; Andersen, Jesper B; Song, Ho-Taek; Judge, Adam D; Seo, Daekwan; Ishikawa, Tsuyoshi; Marquardt, Jens U; Kitade, Mitsuteru; Durkin, Marian E; Raggi, Chiara; Woo, Hyun Goo; Conner, Elizabeth A; Avital, Itzhak; Maclachlan, Ian; Factor, Valentina M; Thorgeirsson, Snorri S

Lee, Yun-Han; Andersen, Jesper B; Song, Ho-Taek; Judge, Adam D; Seo, Daekwan; Ishikawa, Tsuyoshi; Marquardt, Jens U; Kitade, Mitsuteru; Durkin, Marian E; Raggi, Chiara; Woo, Hyun Goo; Conner, Elizabeth A; Avital, Itzhak; Maclachlan, Ian; Factor, Valentina M; Thorgeirsson, Snorri S.

Affiliation

Lee YH; Laboratory of Experimental Carcinogenesis, Center for Cancer Research, Surgery Branch, National Cancer Institute, NIH, Bethesda, Maryland, USA.

Cancer Res ; 70(21): 8264-9, 2010 Nov 01.

Article in En | MEDLINE | ID: mdl-20959491

Subject(s)

Carcinoma, Hepatocellular/metabolism; Carcinoma, Hepatocellular/prevention & control; Liver Neoplasms/metabolism; Liver Neoplasms/prevention & control; Ubiquitin-Protein Ligases/metabolism; Ubiquitin/metabolism; Animals; Biomarkers, Tumor/genetics; Biomarkers, Tumor/metabolism; Blotting, Western; Carcinoma, Hepatocellular/genetics; Cell Cycle; Gene Expression Profiling; Humans; Liver Neoplasms/genetics; Male; Mice; Mice, SCID; Mutation/genetics; Oligonucleotide Array Sequence Analysis; RNA, Messenger/genetics; RNA, Small Interfering/pharmacology; Reverse Transcriptase Polymerase Chain Reaction; Transplantation, Heterologous; Tumor Cells, Cultured; Tumor Suppressor Protein p53/genetics; Tumor Suppressor Protein p53/metabolism; Ubiquitin-Protein Ligases/antagonists & inhibitors; Ubiquitin-Protein Ligases/genetics; Ubiquitination

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Full text: 1 Database: MEDLINE Main subject: Carcinoma, Hepatocellular / Ubiquitin / Ubiquitin-Protein Ligases / Liver Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Cancer Res Year: 2010 Type: Article Affiliation country: United States

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