MRI and DWI: feasibility of DWI and ADC maps in the evaluation of placental changes during gestation.
Prenat Diagn
; 30(12-13): 1178-84, 2010 Dec.
Article
in En
| MEDLINE
| ID: mdl-21064115
ABSTRACT
OBJECTIVE:
To establish if a correlation exists between apparent diffusion coefficient (ADC) values, obtained by diffusion-weighted imaging (DWI), and placental aging.METHOD:
The study is divided into a retrospective phase and a prospective one.In the first phase, 145 pregnant women underwent fetal magnetic resonance imaging (MRI) for suspected disorders in several organs. We performed DWI (b value 0, 200 and 700 s/mm(2)) in all the fetuses, evaluating the patients in whom the whole placenta was visible.In the prospective phase, 50 women (52 fetuses) underwent MRI. We performed, in the same patient, two echo-planar sequences with b values of 0, 200 and 700, and 50, 200 and 700 s/mm(2), including the whole placenta.The ADC maps were calculated for all fetuses, divided into three groups based on gestational age (GA) group I 20-26 weeks' gestation, II 27-33, III 34-40.RESULTS:
In the retrospective phase, ADC values had a range from 1 to 2.4 mm(2)/s, showing a significant correlation between ADC values and GA.ADC values obtained by DWI with b value 0, 200 and 700 s/mm(2) had a range from 0.8 to 2.5 mm(2)/s, with an inverse correlation between ADC values and GA, whereas the ADC values with b value 50, 200 and 700 s/mm(2) did not show any statistical correlation (range 1.5-1.7 mm(2)/s).CONCLUSION:
DWI with ADC maps can not be considered markers for placental aging because they are affected by perfusional and circulatory motion.
Full text:
1
Database:
MEDLINE
Main subject:
Placenta
/
Magnetic Resonance Imaging
/
Gestational Age
/
Diffusion Magnetic Resonance Imaging
Type of study:
Diagnostic_studies
/
Evaluation_studies
/
Observational_studies
/
Prognostic_studies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Prenat Diagn
Year:
2010
Type:
Article
Affiliation country:
Italy