High efficacy of anti DBL4É-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women.
Vaccine
; 29(3): 437-43, 2011 Jan 10.
Article
in En
| MEDLINE
| ID: mdl-21075162
ABSTRACT
Malaria during pregnancy is a major cause of intra-uterine growth-retardation and infant death in sub-Saharan Africa. Ideally, this could be prevented by a vaccine delivered before the first pregnancy. Antibodies against domain DBL4É from VAR2CSA has been shown to inhibit adhesion of laboratory isolates to the placental receptor chondroitin sulfate A. In this study, the binding inhibitory efficacy of IgG elicited by two different DBL4É recombinant proteins was tested on a panel of fresh clinical isolates from pregnant women living in Benin and Tanzania. The most promising recombinant protein elicited antibodies with similar efficacy as pooled plasma from immune multi-gravid African women.
Full text:
1
Database:
MEDLINE
Main subject:
Pregnancy Complications, Infectious
/
Transcription Factors
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Antibodies, Protozoan
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Cell Adhesion
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Malaria, Falciparum
/
DNA Repair Enzymes
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Erythrocytes
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Antigens, Protozoan
Limits:
Female
/
Humans
/
Pregnancy
Country/Region as subject:
Africa
Language:
En
Journal:
Vaccine
Year:
2011
Type:
Article
Affiliation country:
Denmark