Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease.

Chen, Hung-Kai; Ji, Zhong-Sheng; Dodson, Sara E; Miranda, Rene D; Rosenblum, Charles I; Reynolds, Ian J; Freedman, Stephen B; Weisgraber, Karl H; Huang, Yadong; Mahley, Robert W

Chen, Hung-Kai; Ji, Zhong-Sheng; Dodson, Sara E; Miranda, Rene D; Rosenblum, Charles I; Reynolds, Ian J; Freedman, Stephen B; Weisgraber, Karl H; Huang, Yadong; Mahley, Robert W.

Affiliation

Chen HK; Gladstone Center for Translational Research, San Francisco, California 94158, USA.

J Biol Chem ; 286(7): 5215-21, 2011 Feb 18.

Article in En | MEDLINE | ID: mdl-21118811

Subject(s)

Alzheimer Disease/metabolism; Apolipoprotein E4/metabolism; Mitochondria/metabolism; Neurons/metabolism; Alzheimer Disease/genetics; Alzheimer Disease/pathology; Animals; Apolipoprotein E4/genetics; Cell Line, Tumor; Electron Transport/genetics; Electron Transport Chain Complex Proteins/genetics; Electron Transport Chain Complex Proteins/metabolism; Humans; Mice; Mice, Knockout; Mitochondria/genetics; Mitochondria/pathology; Neurons/pathology; Protein Structure, Tertiary; Risk Factors

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Full text: 1 Database: MEDLINE Main subject: Apolipoprotein E4 / Alzheimer Disease / Mitochondria / Neurons Type of study: Etiology_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2011 Type: Article Affiliation country: United States

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