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Stable IgG-like bispecific antibodies directed toward the type I insulin-like growth factor receptor demonstrate enhanced ligand blockade and anti-tumor activity.
Dong, Jianying; Sereno, Arlene; Snyder, William B; Miller, Brian R; Tamraz, Susan; Doern, Adam; Favis, Michael; Wu, Xiufeng; Tran, Hon; Langley, Emma; Joseph, Ingrid; Boccia, Antonio; Kelly, Rebecca; Wortham, Kathleen; Wang, Qin; Berquist, Lisa; Huang, Flora; Gao, Sharon X; Zhang, Ying; Lugovskoy, Alexey; Martin, Shelly; Gouvis, Heather; Berkowitz, Steven; Chiang, Gisela; Reff, Mitchell; Glaser, Scott M; Hariharan, Kandasamy; Demarest, Stephen J.
Affiliation
  • Dong J; Biogen Idec, San Diego, California 92122, USA. jianying_dong@yahoo.com
J Biol Chem ; 286(6): 4703-17, 2011 Feb 11.
Article in En | MEDLINE | ID: mdl-21123183
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Full text: 1 Database: MEDLINE Main subject: Immunoglobulin G / Receptor, IGF Type 1 / Antibodies, Bispecific / Antibodies, Monoclonal, Murine-Derived / Neoplasms, Experimental / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2011 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Immunoglobulin G / Receptor, IGF Type 1 / Antibodies, Bispecific / Antibodies, Monoclonal, Murine-Derived / Neoplasms, Experimental / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2011 Type: Article Affiliation country: United States