Paraoxonase-1 is a major determinant of clopidogrel efficacy.

Bouman, Heleen J; Schömig, Edgar; van Werkum, Jochem W; Velder, Janna; Hackeng, Christian M; Hirschhäuser, Christoph; Waldmann, Christopher; Schmalz, Hans-Günther; ten Berg, Jurriën M; Taubert, Dirk

Bouman, Heleen J; Schömig, Edgar; van Werkum, Jochem W; Velder, Janna; Hackeng, Christian M; Hirschhäuser, Christoph; Waldmann, Christopher; Schmalz, Hans-Günther; ten Berg, Jurriën M; Taubert, Dirk.

Affiliation

Bouman HJ; Department of Cardiology, St. Antonius Hospital Nieuwegein, Nieuwegein, The Netherlands.

Nat Med ; 17(1): 110-6, 2011 Jan.

Article in En | MEDLINE | ID: mdl-21170047

Subject(s)

Aryldialkylphosphatase/genetics; Aryldialkylphosphatase/metabolism; Coronary Disease/surgery; Platelet Aggregation Inhibitors/therapeutic use; Stents; Ticlopidine/analogs & derivatives; Amino Acid Substitution; Biotransformation; Clopidogrel; Coronary Disease/drug therapy; Coronary Disease/mortality; Follow-Up Studies; Genotype; Homozygote; Humans; Kinetics; Polymorphism, Genetic; Substrate Specificity; Survival Analysis; Ticlopidine/metabolism; Ticlopidine/therapeutic use; Time Factors

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Full text: 1 Database: MEDLINE Main subject: Ticlopidine / Platelet Aggregation Inhibitors / Stents / Coronary Disease / Aryldialkylphosphatase Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2011 Type: Article Affiliation country: Netherlands

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