Oncogenically active MYD88 mutations in human lymphoma.

Ngo, Vu N; Young, Ryan M; Schmitz, Roland; Jhavar, Sameer; Xiao, Wenming; Lim, Kian-Huat; Kohlhammer, Holger; Xu, Weihong; Yang, Yandan; Zhao, Hong; Shaffer, Arthur L; Romesser, Paul; Wright, George; Powell, John; Rosenwald, Andreas; Muller-Hermelink, Hans Konrad; Ott, German; Gascoyne, Randy D; Connors, Joseph M; Rimsza, Lisa M; Campo, Elias; Jaffe, Elaine S; Delabie, Jan; Smeland, Erlend B; Fisher, Richard I; Braziel, Rita M; Tubbs, Raymond R; Cook, J R; Weisenburger, Denny D; Chan, Wing C; Staudt, Louis M

Ngo, Vu N; Young, Ryan M; Schmitz, Roland; Jhavar, Sameer; Xiao, Wenming; Lim, Kian-Huat; Kohlhammer, Holger; Xu, Weihong; Yang, Yandan; Zhao, Hong; Shaffer, Arthur L; Romesser, Paul; Wright, George; Powell, John; Rosenwald, Andreas; Muller-Hermelink, Hans Konrad; Ott, German; Gascoyne, Randy D; Connors, Joseph M; Rimsza, Lisa M; Campo, Elias; Jaffe, Elaine S; Delabie, Jan; Smeland, Erlend B; Fisher, Richard I; Braziel, Rita M; Tubbs, Raymond R; Cook, J R; Weisenburger, Denny D; Chan, Wing C; Staudt, Louis M.

Affiliation

Ngo VN; Metabolism Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.

Nature ; 470(7332): 115-9, 2011 Feb 03.

Article in En | MEDLINE | ID: mdl-21179087

Subject(s)

Lymphoma, Large B-Cell, Diffuse/genetics; Lymphoma, Large B-Cell, Diffuse/pathology; Mutation/genetics; Myeloid Differentiation Factor 88/genetics; Myeloid Differentiation Factor 88/metabolism; Oncogenes/genetics; Amino Acid Sequence; Amino Acid Substitution; Burkitt Lymphoma/genetics; Cell Line, Tumor; Cell Survival; Cytokines/metabolism; High-Throughput Nucleotide Sequencing; Humans; Hydrophobic and Hydrophilic Interactions; Interleukin-1 Receptor-Associated Kinases/biosynthesis; Interleukin-1 Receptor-Associated Kinases/genetics; Interleukin-1 Receptor-Associated Kinases/metabolism; Janus Kinases/metabolism; Lymphoma, B-Cell, Marginal Zone/genetics; Lymphoma, Large B-Cell, Diffuse/classification; Molecular Sequence Data; Mutant Proteins/chemistry; Mutant Proteins/genetics; Mutant Proteins/metabolism; Myeloid Differentiation Factor 88/chemistry; NF-kappa B/metabolism; Phosphorylation; Protein Structure, Tertiary; RNA Interference; Receptors, Interleukin-1/metabolism; STAT3 Transcription Factor/metabolism; Sequence Analysis, RNA; Signal Transduction; Toll-Like Receptors/metabolism

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Full text: 1 Database: MEDLINE Main subject: Oncogenes / Lymphoma, Large B-Cell, Diffuse / Myeloid Differentiation Factor 88 / Mutation Limits: Humans Language: En Journal: Nature Year: 2011 Type: Article Affiliation country: United States

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