Autophagy inhibition enhances apoptosis triggered by BO-1051, an N-mustard derivative, and involves the ATM signaling pathway.

Chen, Li-Hsin; Loong, Che-Chuan; Su, Tsann-Long; Lee, Yi-Jang; Chu, Pei-Ming; Tsai, Ming-Long; Tsai, Ping-Hsin; Tu, Pang-Hsien; Chi, Chin-Wen; Lee, Hsin-Chen; Chiou, Shih-Hwa

Chen, Li-Hsin; Loong, Che-Chuan; Su, Tsann-Long; Lee, Yi-Jang; Chu, Pei-Ming; Tsai, Ming-Long; Tsai, Ping-Hsin; Tu, Pang-Hsien; Chi, Chin-Wen; Lee, Hsin-Chen; Chiou, Shih-Hwa.

Affiliation

Chen LH; Department and Institute of Pharmacology, School of Medicine, National Yang-Ming University, 155, Sec 2, Linong Street, Taipei 112, Taiwan.

Biochem Pharmacol ; 81(5): 594-605, 2011 Mar 01.

Article in En | MEDLINE | ID: mdl-21184746

Subject(s)

Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Autophagy/drug effects; Cell Cycle Proteins/physiology; DNA-Binding Proteins/physiology; Nitrogen Mustard Compounds/pharmacology; Protein Serine-Threonine Kinases/physiology; Tumor Suppressor Proteins/physiology; Ataxia Telangiectasia Mutated Proteins; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA Damage; Humans; Liver Neoplasms; Signal Transduction

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Full text: 1 Database: MEDLINE Main subject: Autophagy / Protein Serine-Threonine Kinases / Apoptosis / Cell Cycle Proteins / Tumor Suppressor Proteins / DNA-Binding Proteins / Antineoplastic Agents / Nitrogen Mustard Compounds Limits: Humans Language: En Journal: Biochem Pharmacol Year: 2011 Type: Article Affiliation country: Taiwan

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