Therapeutic efficacy of artesunate-amodiaquine combinations and the plasma and saliva concentrations of desethylamodiaquine in children with acute uncomplicated Plasmodium falciparum malaria.

Sowunmi, Akintunde; Gbotosho, Grace O; Happi, Christian T; Okuboyejo, Titilope M; Sijuade, Abayomi O; Michael, Obaro S; Adewoye, Elsie O; Folarin, Onikepe

Sowunmi, Akintunde; Gbotosho, Grace O; Happi, Christian T; Okuboyejo, Titilope M; Sijuade, Abayomi O; Michael, Obaro S; Adewoye, Elsie O; Folarin, Onikepe.

Affiliation

Sowunmi A; Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria. akinsowunmi@hotmail.com

Am J Ther ; 20(1): 48-56, 2013 Jan.

Article in En | MEDLINE | ID: mdl-21192244

Subject(s)

Amodiaquine/analogs & derivatives; Antimalarials/therapeutic use; Artemisinins/therapeutic use; Malaria, Falciparum/drug therapy; Saliva/chemistry; Acute Disease; Administration, Oral; Amodiaquine/analysis; Amodiaquine/blood; Amodiaquine/pharmacokinetics; Amodiaquine/therapeutic use; Antimalarials/pharmacokinetics; Artemisinins/pharmacokinetics; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Female; Follow-Up Studies; Half-Life; Humans; Infant; Male; Metabolic Clearance Rate; Treatment Outcome

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Full text: 1 Database: MEDLINE Main subject: Saliva / Malaria, Falciparum / Artemisinins / Amodiaquine / Antimalarials Type of study: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Child / Child, preschool / Female / Humans / Infant / Male Language: En Journal: Am J Ther Journal subject: TERAPEUTICA Year: 2013 Type: Article Affiliation country: Nigeria

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