Ammonium chloride and tunicamycin are novel toxins for dopaminergic neurons and induce Parkinson's disease-like phenotypes in medaka fish.

Matsui, Hideaki; Ito, Hidefumi; Taniguchi, Yoshihito; Takeda, Shunichi; Takahashi, Ryosuke

Matsui, Hideaki; Ito, Hidefumi; Taniguchi, Yoshihito; Takeda, Shunichi; Takahashi, Ryosuke.

Affiliation

Matsui H; Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

J Neurochem ; 115(5): 1150-60, 2010 Dec.

Article in En | MEDLINE | ID: mdl-21219329

Subject(s)

Dopamine/physiology; Neurons/drug effects; Neurotoxins/toxicity; Oryzias/physiology; Parkinsonian Disorders/chemically induced; Phenotype; Substantia Nigra/drug effects; Acetylcysteine/analogs & derivatives; Acetylcysteine/toxicity; Ammonium Chloride/toxicity; Animals; Disease Models, Animal; Nerve Tissue Proteins/metabolism; Neurons/pathology; Oryzias/anatomy & histology; Parkinsonian Disorders/pathology; Parkinsonian Disorders/physiopathology; Substantia Nigra/pathology; Substantia Nigra/physiopathology; Tunicamycin/toxicity

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Full text: 1 Database: MEDLINE Main subject: Phenotype / Oryzias / Substantia Nigra / Dopamine / Parkinsonian Disorders / Neurons / Neurotoxins Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Neurochem Year: 2010 Type: Article Affiliation country: Japan

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