Prevention of diabetic nephropathy in rats through enhanced renal antioxidative capacity by inhibition of the proteasome.

Luo, Zhi-Feng; Qi, Wei; Feng, Bing; Mu, Jiao; Zeng, Wei; Guo, Yan-Hong; Pang, Qi; Ye, Zi-Lin; Liu, Li; Yuan, Fa-Huan

Luo, Zhi-Feng; Qi, Wei; Feng, Bing; Mu, Jiao; Zeng, Wei; Guo, Yan-Hong; Pang, Qi; Ye, Zi-Lin; Liu, Li; Yuan, Fa-Huan.

Affiliation

Luo ZF; Institute of Nephrology of Chongqing and Department of Nephrology, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, People's Republic of China.

Life Sci ; 88(11-12): 512-20, 2011 Mar 14.

Article in En | MEDLINE | ID: mdl-21241714

Subject(s)

Antioxidants/metabolism; Diabetic Nephropathies/prevention & control; Kidney/drug effects; Leupeptins/therapeutic use; Protease Inhibitors/therapeutic use; Proteasome Inhibitors; Animals; Blotting, Western; Diabetes Mellitus, Experimental/enzymology; Diabetes Mellitus, Experimental/pathology; Diabetes Mellitus, Experimental/urine; Diabetic Nephropathies/enzymology; Diabetic Nephropathies/pathology; Diabetic Nephropathies/urine; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Kidney/enzymology; Kidney/pathology; Male; Oxidative Stress/drug effects; Proteasome Endopeptidase Complex; Proteinuria/enzymology; Proteinuria/pathology; Proteinuria/prevention & control; Proteinuria/urine; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction

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Full text: 1 Database: MEDLINE Main subject: Protease Inhibitors / Diabetic Nephropathies / Proteasome Inhibitors / Kidney / Leupeptins / Antioxidants Type of study: Prognostic_studies Limits: Animals Language: En Journal: Life Sci Year: 2011 Type: Article

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