An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.

Neganova, Irina; Vilella, Felipe; Atkinson, Stuart P; Lloret, Maria; Passos, João F; von Zglinicki, Thomas; O'Connor, José-Enrique; Burks, Deborah; Jones, Richard; Armstrong, Lyle; Lako, Majlinda

Neganova, Irina; Vilella, Felipe; Atkinson, Stuart P; Lloret, Maria; Passos, João F; von Zglinicki, Thomas; O'Connor, José-Enrique; Burks, Deborah; Jones, Richard; Armstrong, Lyle; Lako, Majlinda.

Affiliation

Neganova I; Institute of Human Genetics, Newcastle University, International Centre for Life, Newcastle upon Tyne, United Kingdom.

Stem Cells ; 29(4): 651-9, 2011 Apr.

Article in En | MEDLINE | ID: mdl-21319273

Subject(s)

Cyclin-Dependent Kinase 2/metabolism; DNA Damage; Embryonic Stem Cells/cytology; Embryonic Stem Cells/metabolism; G1 Phase; S Phase; Apoptosis; Ataxia Telangiectasia Mutated Proteins; BRCA1 Protein/metabolism; Cell Cycle Proteins/metabolism; Cell Line; Cell Proliferation; Cyclin-Dependent Kinase 2/genetics; Cyclin-Dependent Kinase Inhibitor p21/metabolism; DNA Repair; DNA Replication; DNA-Binding Proteins/metabolism; Down-Regulation/genetics; Gene Silencing; Histones/metabolism; Humans; Immunoblotting; Immunoprecipitation; Mass Spectrometry; Protein Serine-Threonine Kinases/metabolism; RNA, Small Interfering; Rad52 DNA Repair and Recombination Protein/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Protein p53/metabolism; Tumor Suppressor Proteins/metabolism

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Full text: 1 Database: MEDLINE Main subject: DNA Damage / G1 Phase / S Phase / Cyclin-Dependent Kinase 2 / Embryonic Stem Cells Limits: Humans Language: En Journal: Stem Cells Year: 2011 Type: Article Affiliation country: United kingdom

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