Cyclosporine alters correlation between free and total mycophenolic acid in kidney transplant recipients in the initial phase.
J Clin Pharm Ther
; 36(2): 217-24, 2011 Apr.
Article
in En
| MEDLINE
| ID: mdl-21366651
ABSTRACT
WHAT IS KNOWN AND OBJECTIVE:
The factors affecting the pharmacokinetics of free mycophenolic acid (MPA) and its phenolic glucuronide (MPAG) are still unclear. The aim of this study was to evaluate the influence of cyclosporine on the pharmacokinetics of free MPA and MPAG.METHODS:
Seventy-seven kidney transplant recipients (23 were in an initial phase and 54 in a stable phase; 41 were treated with cyclosporine and 36 with tacrolimus) were enrolled. Free and total MPA and MPAG were determined using HPLC. The correlations between free and total predose concentrations (C(0) ) of MPA or MPAG were evaluated separately in patients receiving calcineurin inhibitor medications. RESULTS ANDDISCUSSION:
Serum concentration of albumin was lower in the initial phase than in the stable phase. A higher ratio of free MPAG C(0) to free MPA C(0) was observed in cyclosporine-treated than tacrolimus-treated kidney transplant recipients. Free MPA C(0) correlated weakly with total MPA C(0) in kidney transplant recipients treated with cyclosporine in the initial phase (ρ= 0·53, P = 0·06). WHAT IS NEW ANDCONCLUSION:
Cyclosporine increased the ratio of free MPAG C(0) to free MPA C(0) and varied the free fraction of MPA in the hypoalbuminaemic kidney transplant recipients in the initial phase.
Full text:
1
Database:
MEDLINE
Main subject:
Kidney Transplantation
/
Cyclosporine
/
Glucuronides
/
Immunosuppressive Agents
/
Mycophenolic Acid
Type of study:
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Clin Pharm Ther
Journal subject:
FARMACIA
/
TERAPEUTICA
Year:
2011
Type:
Article
Affiliation country:
Japan