Human macrophage responses to clinical isolates from the Mycobacterium tuberculosis complex discriminate between ancient and modern lineages.

Portevin, Damien; Gagneux, Sébastien; Comas, Iñaki; Young, Douglas

Portevin, Damien; Gagneux, Sébastien; Comas, Iñaki; Young, Douglas.

Affiliation

Portevin D; Mycobacterial Research Division, MRC National Institute for Medical Research, London, United Kingdom. dportev@nimr.mrc.ac.uk

PLoS Pathog ; 7(3): e1001307, 2011 Mar.

Article in En | MEDLINE | ID: mdl-21408618

Subject(s)

Host-Pathogen Interactions; Macrophages/immunology; Macrophages/microbiology; Mycobacterium tuberculosis/genetics; Tuberculosis/microbiology; Animals; Biological Evolution; Bone Marrow Cells/metabolism; Chemokines/biosynthesis; Chemokines/blood; Cytokines/biosynthesis; Cytokines/blood; Genetic Variation; Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology; Humans; Immunity, Innate; Mice; Mice, Inbred BALB C; Monocytes/immunology; Mycobacterium tuberculosis/immunology; Phylogeny; Tuberculosis/transmission

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Full text: 1 Database: MEDLINE Main subject: Tuberculosis / Host-Pathogen Interactions / Macrophages / Mycobacterium tuberculosis Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: PLoS Pathog Year: 2011 Type: Article Affiliation country: United kingdom

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