Mechanism of cell death mediated by a BF2-chelated tetraaryl-azadipyrromethene photodynamic therapeutic: dissection of the apoptotic pathway in vitro and in vivo.

O'Connor, Aisling E; Mc Gee, Margaret M; Likar, Yury; Ponomarev, Vladimir; Callanan, John J; O'shea, Donal F; Byrne, Annette T; Gallagher, William M

O'Connor, Aisling E; Mc Gee, Margaret M; Likar, Yury; Ponomarev, Vladimir; Callanan, John J; O'shea, Donal F; Byrne, Annette T; Gallagher, William M.

Affiliation

O'Connor AE; UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.

Int J Cancer ; 130(3): 705-15, 2012 Feb 01.

Article in En | MEDLINE | ID: mdl-21413012

Subject(s)

Apoptosis; Photochemotherapy; Photosensitizing Agents/pharmacology; Pyrroles/pharmacology; Animals; Apoptosis/drug effects; Caspases/metabolism; Cell Line, Tumor; Endoplasmic Reticulum Stress/drug effects; Female; HCT116 Cells; Humans; Luminescent Measurements; Mice; Mice, Inbred BALB C; Mice, Nude; Positron-Emission Tomography; Protein Unfolding/drug effects; Reactive Oxygen Species/metabolism; Signal Transduction/drug effects; Xenograft Model Antitumor Assays

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Full text: 1 Database: MEDLINE Main subject: Photochemotherapy / Pyrroles / Photosensitizing Agents / Apoptosis Limits: Animals / Female / Humans Language: En Journal: Int J Cancer Year: 2012 Type: Article Affiliation country: Ireland

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