Cardiac myosin activation: a potential therapeutic approach for systolic heart failure.

Malik, Fady I; Hartman, James J; Elias, Kathleen A; Morgan, Bradley P; Rodriguez, Hector; Brejc, Katjusa; Anderson, Robert L; Sueoka, Sandra H; Lee, Kenneth H; Finer, Jeffrey T; Sakowicz, Roman; Baliga, Ramesh; Cox, David R; Garard, Marc; Godinez, Guillermo; Kawas, Raja; Kraynack, Erica; Lenzi, David; Lu, Pu Ping; Muci, Alexander; Niu, Congrong; Qian, Xiangping; Pierce, Daniel W; Pokrovskii, Maria; Suehiro, Ion; Sylvester, Sheila; Tochimoto, Todd; Valdez, Corey; Wang, Wenyue; Katori, Tatsuo; Kass, David A; Shen, You-Tang; Vatner, Stephen F; Morgans, David J

Malik, Fady I; Hartman, James J; Elias, Kathleen A; Morgan, Bradley P; Rodriguez, Hector; Brejc, Katjusa; Anderson, Robert L; Sueoka, Sandra H; Lee, Kenneth H; Finer, Jeffrey T; Sakowicz, Roman; Baliga, Ramesh; Cox, David R; Garard, Marc; Godinez, Guillermo; Kawas, Raja; Kraynack, Erica; Lenzi, David; Lu, Pu Ping; Muci, Alexander; Niu, Congrong; Qian, Xiangping; Pierce, Daniel W; Pokrovskii, Maria; Suehiro, Ion; Sylvester, Sheila; Tochimoto, Todd; Valdez, Corey; Wang, Wenyue; Katori, Tatsuo; Kass, David A; Shen, You-Tang; Vatner, Stephen F; Morgans, David J.

Affiliation

Malik FI; Preclinical Research and Development, Cytokinetics, Inc., South San Francisco, CA 94080, USA. fmalik@cytokinetics.com

Science ; 331(6023): 1439-43, 2011 Mar 18.

Article in En | MEDLINE | ID: mdl-21415352

Subject(s)

Cardiac Myosins/metabolism; Heart Failure, Systolic/drug therapy; Myocardial Contraction/drug effects; Myocytes, Cardiac/drug effects; Urea/analogs & derivatives; Actin Cytoskeleton/metabolism; Actins/metabolism; Adenosine Triphosphatases/metabolism; Adenosine Triphosphate/metabolism; Adrenergic beta-Agonists/pharmacology; Allosteric Regulation; Animals; Binding Sites; Calcium/metabolism; Cardiac Myosins/chemistry; Cardiac Output/drug effects; Dogs; Female; Heart Failure, Systolic/physiopathology; Isoproterenol/pharmacology; Male; Myocytes, Cardiac/physiology; Phosphates/metabolism; Protein Binding; Protein Conformation; Protein Isoforms/chemistry; Protein Isoforms/metabolism; Rats; Rats, Sprague-Dawley; Urea/chemistry; Urea/metabolism; Urea/pharmacology; Ventricular Function, Left/drug effects

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Full text: 1 Database: MEDLINE Main subject: Urea / Cardiac Myosins / Myocytes, Cardiac / Heart Failure, Systolic / Myocardial Contraction Type of study: Prognostic_studies Limits: Animals Language: En Journal: Science Year: 2011 Type: Article Affiliation country: United States

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