Anchoring interferon alpha to apolipoprotein A-I reduces hematological toxicity while enhancing immunostimulatory properties.

Fioravanti, Jessica; González, Iranzu; Medina-Echeverz, José; Larrea, Esther; Ardaiz, Nuria; González-Aseguinolaza, Gloria; Prieto, Jesús; Berraondo, Pedro

Fioravanti, Jessica; González, Iranzu; Medina-Echeverz, José; Larrea, Esther; Ardaiz, Nuria; González-Aseguinolaza, Gloria; Prieto, Jesús; Berraondo, Pedro.

Affiliation

Fioravanti J; Division of Hepatology and Gene Therapy, Center for Applied Medical Research, University of Navarra, Pamplona, Navarra, Spain.

Hepatology ; 53(6): 1864-73, 2011 Jun.

Article in En | MEDLINE | ID: mdl-21425312

Subject(s)

Apolipoprotein A-I/pharmacokinetics; Hepatitis C/immunology; Immunization; Interferon-alpha/pharmacokinetics; Liver/metabolism; Liver/virology; Recombinant Fusion Proteins/pharmacokinetics; Animals; Antiviral Agents/pharmacokinetics; Antiviral Agents/pharmacology; Antiviral Agents/therapeutic use; Apolipoprotein A-I/pharmacology; Apolipoprotein A-I/therapeutic use; Apoptosis/drug effects; CD36 Antigens/genetics; CD36 Antigens/physiology; Cell Line; Cell Line, Tumor; Disease Models, Animal; Female; Half-Life; Hepacivirus/drug effects; Hepacivirus/isolation & purification; Hepatitis C/drug therapy; Hepatitis C/physiopathology; Interferon-alpha/pharmacology; Interferon-alpha/therapeutic use; Lymphocytes/drug effects; Lymphocytes/pathology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Receptor Cross-Talk/physiology; Receptor, Interferon alpha-beta/physiology; Recombinant Fusion Proteins/pharmacology; Recombinant Fusion Proteins/therapeutic use

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Full text: 1 Database: MEDLINE Main subject: Recombinant Fusion Proteins / Immunization / Interferon-alpha / Apolipoprotein A-I / Hepatitis C / Liver Limits: Animals Language: En Journal: Hepatology Year: 2011 Type: Article Affiliation country: Spain

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