Network-guided analysis of genes with altered somatic copy number and gene expression reveals pathways commonly perturbed in metastatic melanoma.

Valsesia, Armand; Rimoldi, Donata; Martinet, Danielle; Ibberson, Mark; Benaglio, Paola; Quadroni, Manfredo; Waridel, Patrice; Gaillard, Muriel; Pidoux, Mireille; Rapin, Blandine; Rivolta, Carlo; Xenarios, Ioannis; Simpson, Andrew J G; Antonarakis, Stylianos E; Beckmann, Jacques S; Jongeneel, C Victor; Iseli, Christian; Stevenson, Brian J

Valsesia, Armand; Rimoldi, Donata; Martinet, Danielle; Ibberson, Mark; Benaglio, Paola; Quadroni, Manfredo; Waridel, Patrice; Gaillard, Muriel; Pidoux, Mireille; Rapin, Blandine; Rivolta, Carlo; Xenarios, Ioannis; Simpson, Andrew J G; Antonarakis, Stylianos E; Beckmann, Jacques S; Jongeneel, C Victor; Iseli, Christian; Stevenson, Brian J.

Affiliation

Valsesia A; Ludwig Institute for Cancer Research, Lausanne, Switzerland.

PLoS One ; 6(4): e18369, 2011 Apr 08.

Article in En | MEDLINE | ID: mdl-21494657

Subject(s)

DNA Copy Number Variations/genetics; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks/genetics; Genes, Neoplasm/genetics; Melanoma/genetics; Melanoma/pathology; Signal Transduction/genetics; Cell Line, Tumor; Comparative Genomic Hybridization; Databases, Genetic; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Neoplasm Metastasis; Polymorphism, Single Nucleotide/genetics; Proto-Oncogene Proteins c-mdm2/genetics; RNA, Messenger/genetics; RNA, Messenger/metabolism

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Full text: 1 Database: MEDLINE Main subject: Signal Transduction / Gene Expression Regulation, Neoplastic / Genes, Neoplasm / Gene Regulatory Networks / DNA Copy Number Variations / Melanoma Limits: Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2011 Type: Article Affiliation country: Switzerland

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