Screening and identification of a novel class of TGF-ß type 1 receptor kinase inhibitor.

Huynh, Q Khai; Wise, Sarah J; Koch, Keith A; Castonguay, Laurie A; Reid, Brian G; Pagratis, Erinn E; Koditek, David; Glascock, Christopher B; Pitts, Kelly R; Turner, Benjamin A; Liu, Xiaohong; Hung, Magdeleine; Han, Bin; Pagratis, Nikos

Huynh, Q Khai; Wise, Sarah J; Koch, Keith A; Castonguay, Laurie A; Reid, Brian G; Pagratis, Erinn E; Koditek, David; Glascock, Christopher B; Pitts, Kelly R; Turner, Benjamin A; Liu, Xiaohong; Hung, Magdeleine; Han, Bin; Pagratis, Nikos.

Affiliation

Huynh QK; Research and Development, Gilead Sciences, Inc., Foster City, CA 94404, USA. khai.huynh@gilead.com

J Biomol Screen ; 16(7): 724-33, 2011 Aug.

Article in En | MEDLINE | ID: mdl-21521800

Subject(s)

High-Throughput Screening Assays; Protein Kinase Inhibitors/pharmacology; Protein Serine-Threonine Kinases/antagonists & inhibitors; Receptors, Transforming Growth Factor beta/antagonists & inhibitors; Adenosine Diphosphate/metabolism; Cell Line, Tumor; Computer Simulation; Fluorescence Resonance Energy Transfer; Fluoroimmunoassay; Humans; Kinetics; Molecular Conformation; Phosphorylation/drug effects; Protein Kinase Inhibitors/chemistry; Protein Serine-Threonine Kinases/metabolism; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta/metabolism; Smad Proteins/metabolism; Small Molecule Libraries/pharmacology; Transforming Growth Factor beta/pharmacology

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Full text: 1 Database: MEDLINE Main subject: Protein Serine-Threonine Kinases / Receptors, Transforming Growth Factor beta / Protein Kinase Inhibitors / High-Throughput Screening Assays Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Humans Language: En Journal: J Biomol Screen Journal subject: BIOLOGIA MOLECULAR Year: 2011 Type: Article Affiliation country: United States

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