[A new era in rat genetics]. / Une nouvelle ère pour la génétique du rat.
Med Sci (Paris)
; 27(4): 387-90, 2011 Apr.
Article
in Fr
| MEDLINE
| ID: mdl-21524403
ABSTRACT
Rat and mice are privileged tools for scientists. However, despite obvious advantages, such as a larger size, more faithful reproduction of human diseases, and utility for physiological and cognitive studies, rats have suffered from limited genetic technologies such as targeted mutagenesis. However, the gap between rat and mouse for genetic approaches will soon disappear with the recent advances of zinc finger nucleases applicable to early-stage rat embryos and the successful derivation of germ line competent rat ES cells, almost thirty years after murine ES cells. This will lead to new opportunities and to increase our capacity to model human pathologies.
Full text:
1
Database:
MEDLINE
Main subject:
Rats
/
Genetic Techniques
Type of study:
Prognostic_studies
Limits:
Animals
Language:
Fr
Journal:
Med Sci (Paris)
Journal subject:
MEDICINA
Year:
2011
Type:
Article
Affiliation country:
France