Tetrazine-trans-cyclooctene ligation for the rapid construction of integrin &#945;vß3 targeted PET tracer based on a cyclic RGD peptide.

Selvaraj, Ramajeyam; Liu, Shuanglong; Hassink, Matthew; Huang, Chiun-Wei; Yap, Li-Peng; Park, Ryan; Fox, Joseph M; Li, Zibo; Conti, Peter S

Tetrazine-trans-cyclooctene ligation for the rapid construction of integrin αvß3 targeted PET tracer based on a cyclic RGD peptide.

Selvaraj, Ramajeyam; Liu, Shuanglong; Hassink, Matthew; Huang, Chiun-Wei; Yap, Li-Peng; Park, Ryan; Fox, Joseph M; Li, Zibo; Conti, Peter S.

Affiliation

Selvaraj R; Brown Laboratories, Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19803, USA.

Bioorg Med Chem Lett ; 21(17): 5011-4, 2011 Sep 01.

Article in En | MEDLINE | ID: mdl-21601452

Subject(s)

Cyclooctanes/chemistry; Integrin alphaVbeta3/chemistry; Oligopeptides/chemistry; Positron-Emission Tomography; Tetrazoles/chemistry; Animals; Catalysis; Cell Line; Chromatography, High Pressure Liquid; Female; Kinetics; Mice; Mice, Nude; Neoplasms, Experimental/diagnostic imaging; Radiometry; Transplantation, Heterologous

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Full text: 1 Database: MEDLINE Main subject: Oligopeptides / Tetrazoles / Cyclooctanes / Integrin alphaVbeta3 / Positron-Emission Tomography Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2011 Type: Article Affiliation country: United States

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