Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1&#945; (HIF1A) and result in differential HIF1A-dependent gene expression.

Jantsch, Jonathan; Wiese, Melanie; Schödel, Johannes; Castiglione, Kirstin; Gläsner, Joachim; Kolbe, Sophie; Mole, David; Schleicher, Ulrike; Eckardt, Kai-Uwe; Hensel, Michael; Lang, Roland; Bogdan, Christian; Schnare, Markus; Willam, Carsten

Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression.

Jantsch, Jonathan; Wiese, Melanie; Schödel, Johannes; Castiglione, Kirstin; Gläsner, Joachim; Kolbe, Sophie; Mole, David; Schleicher, Ulrike; Eckardt, Kai-Uwe; Hensel, Michael; Lang, Roland; Bogdan, Christian; Schnare, Markus; Willam, Carsten.

Affiliation

Jantsch J; Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. jonathan.jantsch@uk-erlangen.de

J Leukoc Biol ; 90(3): 551-62, 2011 Sep.

Article in En | MEDLINE | ID: mdl-21685248

Subject(s)

Adaptor Proteins, Vesicular Transport/physiology; Gene Expression Profiling; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Hypoxia; Myeloid Differentiation Factor 88/physiology; Signal Transduction; Toll-Like Receptor 4/physiology; Animals; Biomarkers/metabolism; Blotting, Western; Cell Differentiation; Cell Proliferation; Chromatin Immunoprecipitation; Dendritic Cells/drug effects; Dendritic Cells/metabolism; Hypoxia-Inducible Factor 1, alpha Subunit/genetics; Lipopolysaccharides/pharmacology; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B/genetics; NF-kappa B/metabolism; Oligonucleotide Array Sequence Analysis; RNA, Messenger/genetics; Reverse Transcriptase Polymerase Chain Reaction

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Full text: 1 Database: MEDLINE Main subject: Signal Transduction / Gene Expression Profiling / Adaptor Proteins, Vesicular Transport / Hypoxia-Inducible Factor 1, alpha Subunit / Toll-Like Receptor 4 / Myeloid Differentiation Factor 88 / Hypoxia Limits: Animals Language: En Journal: J Leukoc Biol Year: 2011 Type: Article Affiliation country: Germany

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