FK506 ameliorates cell death features in Huntington's disease striatal cell models.

Rosenstock, Tatiana R; de Brito, Olga Martins; Lombardi, Vitoria; Louros, Susana; Ribeiro, Marcio; Almeida, Sandra; Ferreira, Ildete Luisa; Oliveira, Catarina R; Rego, A Cristina

Rosenstock, Tatiana R; de Brito, Olga Martins; Lombardi, Vitoria; Louros, Susana; Ribeiro, Marcio; Almeida, Sandra; Ferreira, Ildete Luisa; Oliveira, Catarina R; Rego, A Cristina.

Affiliation

Rosenstock TR; Center for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

Neurochem Int ; 59(5): 600-9, 2011 Oct.

Article in En | MEDLINE | ID: mdl-21703318

Subject(s)

Corpus Striatum/cytology; Corpus Striatum/drug effects; Huntington Disease/pathology; Immunosuppressive Agents/pharmacology; Neurons/drug effects; Neuroprotective Agents; Tacrolimus/pharmacology; Animals; Apoptosis/drug effects; Blotting, Western; Caspase 3/metabolism; Cell Death; Cell Line; Cytosol/metabolism; DNA Fragmentation; Humans; Huntingtin Protein; Mice; Mice, Transgenic; Mitochondria/metabolism; Necrosis; Nerve Tissue Proteins/genetics; Nitro Compounds/toxicity; Nuclear Proteins/genetics; Propionates/toxicity; Staurosporine/pharmacology; Subcellular Fractions/drug effects; Subcellular Fractions/metabolism

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Full text: 1 Database: MEDLINE Main subject: Tacrolimus / Huntington Disease / Neuroprotective Agents / Corpus Striatum / Immunosuppressive Agents / Neurons Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Neurochem Int Year: 2011 Type: Article Affiliation country: Portugal

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