Phosphodiesterase-4 inhibition combined with isoniazid treatment of rabbits with pulmonary tuberculosis reduces macrophage activation and lung pathology.

Subbian, Selvakumar; Tsenova, Liana; O'Brien, Paul; Yang, Guibin; Koo, Mi-Sun; Peixoto, Blas; Fallows, Dorothy; Zeldis, Jerome B; Muller, George; Kaplan, Gilla

Subbian, Selvakumar; Tsenova, Liana; O'Brien, Paul; Yang, Guibin; Koo, Mi-Sun; Peixoto, Blas; Fallows, Dorothy; Zeldis, Jerome B; Muller, George; Kaplan, Gilla.

Affiliation

Subbian S; Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute at the University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA.

Am J Pathol ; 179(1): 289-301, 2011 Jul.

Article in En | MEDLINE | ID: mdl-21703411

Subject(s)

Antitubercular Agents/therapeutic use; Cyclic Nucleotide Phosphodiesterases, Type 4/chemistry; Isoniazid/therapeutic use; Lung/pathology; Macrophage Activation/drug effects; Thalidomide/analogs & derivatives; Tuberculosis, Pulmonary/prevention & control; Animals; Blotting, Western; Colony-Forming Units Assay; Cyclic Nucleotide Phosphodiesterases, Type 4/metabolism; Cytokines/metabolism; Drug Synergism; Drug Therapy, Combination; Female; Lung/drug effects; Male; Matrix Metalloproteinases/metabolism; Mycobacterium tuberculosis/pathogenicity; Phosphodiesterase 4 Inhibitors/therapeutic use; Pulmonary Fibrosis/enzymology; Pulmonary Fibrosis/pathology; Pulmonary Fibrosis/prevention & control; RNA, Messenger/genetics; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; Thalidomide/therapeutic use; Tuberculosis, Pulmonary/enzymology; Tuberculosis, Pulmonary/pathology

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Full text: 1 Database: MEDLINE Main subject: Thalidomide / Tuberculosis, Pulmonary / Cyclic Nucleotide Phosphodiesterases, Type 4 / Isoniazid / Lung / Macrophage Activation / Antitubercular Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Pathol Year: 2011 Type: Article Affiliation country: United States

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