Metabotropic glutamate receptor 5 antagonist protects dopaminergic and noradrenergic neurons from degeneration in MPTP-treated monkeys.

Masilamoni, Gunasingh J; Bogenpohl, James W; Alagille, David; Delevich, Kristen; Tamagnan, Gilles; Votaw, John R; Wichmann, Thomas; Smith, Yoland

Masilamoni, Gunasingh J; Bogenpohl, James W; Alagille, David; Delevich, Kristen; Tamagnan, Gilles; Votaw, John R; Wichmann, Thomas; Smith, Yoland.

Affiliation

Masilamoni GJ; Yerkes National Primate Research Center, Emory University, 954 Gatewood Rd NE, Atlanta, GA 30329, USA. gjeyara@emory.edu

Brain ; 134(Pt 7): 2057-73, 2011 Jul.

Article in En | MEDLINE | ID: mdl-21705423

Subject(s)

Brain/pathology; Dopamine/metabolism; Excitatory Amino Acid Antagonists/therapeutic use; MPTP Poisoning/complications; Nerve Degeneration; Neurons/drug effects; Norepinephrine/metabolism; Receptors, Metabotropic Glutamate/antagonists & inhibitors; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/pharmacology; Analysis of Variance; Animals; Brain/diagnostic imaging; Brain Mapping; Calbindins; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Fluorine Radioisotopes; MPTP Poisoning/diagnostic imaging; Macaca mulatta; Nerve Degeneration/etiology; Nerve Degeneration/pathology; Nerve Degeneration/prevention & control; Nortropanes/pharmacokinetics; Positron-Emission Tomography; Protein Binding/drug effects; Pyridines/pharmacology; Receptor, Metabotropic Glutamate 5; S100 Calcium Binding Protein G/metabolism; Thiazoles/pharmacology; Tyrosine 3-Monooxygenase/metabolism

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Full text: 1 Database: MEDLINE Main subject: Brain / Dopamine / Norepinephrine / Receptors, Metabotropic Glutamate / Excitatory Amino Acid Antagonists / MPTP Poisoning / Nerve Degeneration / Neurons Type of study: Etiology_studies Limits: Animals Language: En Journal: Brain Year: 2011 Type: Article Affiliation country: United States

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