Treatment-induced oxidative stress and cellular antioxidant capacity determine response to bortezomib in mantle cell lymphoma.

Weniger, Marc A; Rizzatti, Edgar G; Pérez-Galán, Patricia; Liu, Delong; Wang, Qiuyan; Munson, Peter J; Raghavachari, Nalini; White, Therese; Tweito, Megan M; Dunleavy, Kieron; Ye, Yihong; Wilson, Wyndham H; Wiestner, Adrian

Weniger, Marc A; Rizzatti, Edgar G; Pérez-Galán, Patricia; Liu, Delong; Wang, Qiuyan; Munson, Peter J; Raghavachari, Nalini; White, Therese; Tweito, Megan M; Dunleavy, Kieron; Ye, Yihong; Wilson, Wyndham H; Wiestner, Adrian.

Affiliation

Weniger MA; Hematology Branch, NHLBI, NIH, Building 10, CRC 3-5140, 10 Center Drive, Bethesda, 20892 MD, USA.

Clin Cancer Res ; 17(15): 5101-12, 2011 Aug 01.

Article in En | MEDLINE | ID: mdl-21712452

Subject(s)

Antineoplastic Agents/therapeutic use; Antioxidants/pharmacology; Boronic Acids/therapeutic use; Lymphoma, Mantle-Cell/drug therapy; Proteasome Inhibitors; Pyrazines/therapeutic use; Antineoplastic Agents/pharmacology; Boronic Acids/pharmacology; Bortezomib; Cell Survival; Drug Resistance, Neoplasm; Endoplasmic Reticulum/drug effects; Gene Expression Profiling; Humans; Lymphoma, Mantle-Cell/metabolism; NF-E2-Related Factor 2/pharmacology; Oxidative Stress/drug effects; Proteasome Endopeptidase Complex/metabolism; Pyrazines/pharmacology; Stress, Physiological/drug effects; Transcription, Genetic/drug effects; Tumor Cells, Cultured

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Full text: 1 Database: MEDLINE Main subject: Pyrazines / Boronic Acids / Lymphoma, Mantle-Cell / Proteasome Inhibitors / Antineoplastic Agents / Antioxidants Limits: Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2011 Type: Article Affiliation country: United States

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