Functionally biased modulation of A(3) adenosine receptor agonist efficacy and potency by imidazoquinolinamine allosteric enhancers.

Gao, Zhan-Guo; Verzijl, Dennis; Zweemer, Annelien; Ye, Kai; Göblyös, Anikó; Ijzerman, Adriaan P; Jacobson, Kenneth A

Gao, Zhan-Guo; Verzijl, Dennis; Zweemer, Annelien; Ye, Kai; Göblyös, Anikó; Ijzerman, Adriaan P; Jacobson, Kenneth A.

Affiliation

Gao ZG; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0810, USA. zg21o@nih.gov

Biochem Pharmacol ; 82(6): 658-68, 2011 Sep 15.

Article in En | MEDLINE | ID: mdl-21718691

Subject(s)

Adenosine A3 Receptor Agonists/pharmacology; Aminoquinolines/pharmacology; Imidazoles/pharmacology; Receptor, Adenosine A3/metabolism; Adenosine A3 Receptor Agonists/chemistry; Allosteric Regulation/drug effects; Aminoquinolines/chemistry; Animals; Arrestins/metabolism; CHO Cells; Calcium/metabolism; Computer Simulation; Cricetinae; Cricetulus; Cyclic AMP/metabolism; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Humans; Imidazoles/chemistry; Membrane Potentials/drug effects; Molecular Structure; Receptor, Adenosine A3/genetics; Transfection; beta-Arrestins

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Full text: 1 Database: MEDLINE Main subject: Receptor, Adenosine A3 / Adenosine A3 Receptor Agonists / Aminoquinolines / Imidazoles Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Biochem Pharmacol Year: 2011 Type: Article Affiliation country: United States

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