Interaction of the ARF tumor suppressor with cytosolic HSP70 contributes to its autophagy function.

Pimkina, Julia; Murphy, Maureen E

Pimkina, Julia; Murphy, Maureen E.

Affiliation

Pimkina J; Program in Developmental Therapeutics, Philadelphia, PA, USA.

Cancer Biol Ther ; 12(6): 503-9, 2011 Sep 15.

Article in En | MEDLINE | ID: mdl-21738007

Subject(s)

Autophagy; Cyclin-Dependent Kinase Inhibitor p16/metabolism; HSP70 Heat-Shock Proteins/metabolism; Mitochondrial Proteins/metabolism; Tumor Suppressor Protein p14ARF/metabolism; Animals; Cell Line; Cell Survival/drug effects; Cyclin-Dependent Kinase Inhibitor p16/genetics; Cytosol/metabolism; Gene Knockdown Techniques; Gene Knockout Techniques; HSP70 Heat-Shock Proteins/antagonists & inhibitors; Humans; Immunoprecipitation; Mice; Mitochondria/metabolism; Mitochondrial Proteins/antagonists & inhibitors; Protein Binding; Protein Transport; RNA Interference; Sulfonamides/pharmacology; Tumor Suppressor Protein p53/genetics; Tumor Suppressor Protein p53/metabolism

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Full text: 1 Database: MEDLINE Main subject: Autophagy / HSP70 Heat-Shock Proteins / Cyclin-Dependent Kinase Inhibitor p16 / Tumor Suppressor Protein p14ARF / Mitochondrial Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cancer Biol Ther Journal subject: NEOPLASIAS / TERAPEUTICA Year: 2011 Type: Article Affiliation country: United States

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