Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis.

Irrinki, Krishna M; Mallilankaraman, Karthik; Thapa, Roshan J; Chandramoorthy, Harish C; Smith, Frank J; Jog, Neelakshi R; Gandhirajan, Rajesh Kumar; Kelsen, Steven G; Houser, Steven R; May, Michael J; Balachandran, Siddharth; Madesh, Muniswamy

Irrinki, Krishna M; Mallilankaraman, Karthik; Thapa, Roshan J; Chandramoorthy, Harish C; Smith, Frank J; Jog, Neelakshi R; Gandhirajan, Rajesh Kumar; Kelsen, Steven G; Houser, Steven R; May, Michael J; Balachandran, Siddharth; Madesh, Muniswamy.

Affiliation

Irrinki KM; Department of Biochemistry, Temple University, Philadelphia, PA 19140, USA.

Mol Cell Biol ; 31(18): 3745-58, 2011 Sep.

Article in En | MEDLINE | ID: mdl-21746883

Subject(s)

Apoptosis/physiology; Fas-Associated Death Domain Protein/metabolism; Intracellular Signaling Peptides and Proteins/metabolism; Necrosis/metabolism; Tumor Necrosis Factor-alpha/metabolism; bcl-2 Homologous Antagonist-Killer Protein/metabolism; bcl-2-Associated X Protein/metabolism; Animals; Blotting, Western; Flow Cytometry; GTPase-Activating Proteins/metabolism; Gene Knockout Techniques; Immunoprecipitation; Membrane Potential, Mitochondrial; Mice; Mitochondria/metabolism; NF-kappa B/metabolism; Reactive Oxygen Species; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism; Signal Transduction; Transcription Factor RelA/antagonists & inhibitors; Transcription Factor RelA/genetics; bcl-2 Homologous Antagonist-Killer Protein/deficiency; bcl-2-Associated X Protein/deficiency

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Full text: 1 Database: MEDLINE Main subject: Tumor Necrosis Factor-alpha / Apoptosis / Intracellular Signaling Peptides and Proteins / Bcl-2-Associated X Protein / Bcl-2 Homologous Antagonist-Killer Protein / Fas-Associated Death Domain Protein / Necrosis Limits: Animals Language: En Journal: Mol Cell Biol Year: 2011 Type: Article Affiliation country: United States

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