A novel EPO receptor agonist improves glucose tolerance via glucose uptake in skeletal muscle in a mouse model of diabetes.

Scully, Michael S; Ort, Tatiana A; James, Ian E; Bugelski, Peter J; Makropoulos, Dorie A; Deutsch, Heather A; Pieterman, Elsbet J; van den Hoek, Anita M; Havekes, Louis M; Dubell, William H; Wertheimer, Joshua D; Picha, Kristen M

Scully, Michael S; Ort, Tatiana A; James, Ian E; Bugelski, Peter J; Makropoulos, Dorie A; Deutsch, Heather A; Pieterman, Elsbet J; van den Hoek, Anita M; Havekes, Louis M; Dubell, William H; Wertheimer, Joshua D; Picha, Kristen M.

Affiliation

Scully MS; Discovery Research, Centocor R&D Inc., 145 King of Prussia Road, Radnor, PA 19087, USA.

Exp Diabetes Res ; 2011: 910159, 2011.

Article in En | MEDLINE | ID: mdl-21754921

Subject(s)

Diabetes Mellitus, Experimental/metabolism; Glucose/metabolism; Muscle, Skeletal/drug effects; Muscle, Skeletal/metabolism; Receptors, Erythropoietin/agonists; Recombinant Fusion Proteins/pharmacology; Animals; Darbepoetin alfa; Diabetes Mellitus, Experimental/etiology; Diabetes Mellitus, Experimental/physiopathology; Dietary Fats/adverse effects; Disease Models, Animal; Dose-Response Relationship, Drug; Epoetin Alfa; Erythropoietin/analogs & derivatives; Erythropoietin/pharmacology; Glucose Clamp Technique; Glucose Tolerance Test; Insulin Resistance/physiology; Male; Mice; Mice, Inbred C57BL; Obesity/complications; Obesity/etiology; Obesity/metabolism; Recombinant Proteins; Time Factors

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Full text: 1 Database: MEDLINE Main subject: Recombinant Fusion Proteins / Receptors, Erythropoietin / Muscle, Skeletal / Diabetes Mellitus, Experimental / Glucose Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Exp Diabetes Res Journal subject: ENDOCRINOLOGIA Year: 2011 Type: Article Affiliation country: United States

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