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Sildenafil attenuates TNBS-induced colitis in rats: possible involvement of cGMP and KATP channels.
Fakhfouri, Gohar; Rahimian, Reza; Hashemi, Saeed; Rasouli, Mohammad Reza; Bahremand, Arash; Mehr, Shahram Ejtemaei; Khorramizadeh, Mohammad Reza; Dehpour, Ahmad Reza.
Affiliation
  • Fakhfouri G; Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Fundam Clin Pharmacol ; 26(2): 190-3, 2012 Apr.
Article in En | MEDLINE | ID: mdl-21777273
ABSTRACT
The involvement of cGMP/KATP pathway in effects of sildenafil on experimental colitis was investigated. Sildenafil significantly attenuated colonic injury markers. These effects were reversed by the addition of glibenclamide or ODQ, indicating the involvement of ATP-sensitive potassium channels (KATP) and cGMP, respectively.
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Full text: 1 Database: MEDLINE Main subject: Piperazines / Sulfones / Colitis / Cyclic GMP / KATP Channels Limits: Animals Language: En Journal: Fundam Clin Pharmacol Journal subject: FARMACOLOGIA Year: 2012 Type: Article Affiliation country: Iran
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Full text: 1 Database: MEDLINE Main subject: Piperazines / Sulfones / Colitis / Cyclic GMP / KATP Channels Limits: Animals Language: En Journal: Fundam Clin Pharmacol Journal subject: FARMACOLOGIA Year: 2012 Type: Article Affiliation country: Iran