FTY720 blocks egress of T cells in part by abrogation of their adhesion on the lymph node sinus.

Zhi, Liang; Kim, Pilhan; Thompson, Brian D; Pitsillides, Costas; Bankovich, Alexander J; Yun, Seok-Hyun; Lin, Charles P; Cyster, Jason G; Wu, Mei X

Zhi, Liang; Kim, Pilhan; Thompson, Brian D; Pitsillides, Costas; Bankovich, Alexander J; Yun, Seok-Hyun; Lin, Charles P; Cyster, Jason G; Wu, Mei X.

Affiliation

Zhi L; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.

J Immunol ; 187(5): 2244-51, 2011 Sep 01.

Article in En | MEDLINE | ID: mdl-21788441

Subject(s)

Chemotaxis, Leukocyte/drug effects; Immunosuppressive Agents/pharmacology; Propylene Glycols/pharmacology; Sphingosine/analogs & derivatives; T-Lymphocytes/drug effects; Animals; Cell Adhesion/drug effects; Cell Adhesion/immunology; Cell Separation; Chemotaxis, Leukocyte/immunology; Fingolimod Hydrochloride; Flow Cytometry; GTP-Binding Protein alpha Subunit, Gi2/genetics; GTP-Binding Protein alpha Subunit, Gi2/immunology; GTP-Binding Protein alpha Subunit, Gi2/metabolism; Lymph Nodes/cytology; Lymph Nodes/drug effects; Lymph Nodes/immunology; Mice; Mice, Knockout; Receptors, Lysosphingolipid/agonists; Sphingosine/pharmacology; T-Lymphocytes/immunology; T-Lymphocytes/metabolism

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Full text: 1 Database: MEDLINE Main subject: Propylene Glycols / Sphingosine / T-Lymphocytes / Chemotaxis, Leukocyte / Immunosuppressive Agents Limits: Animals Language: En Journal: J Immunol Year: 2011 Type: Article Affiliation country: United States

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