Ab-IL2 fusion proteins mediate NK cell immune synapse formation by polarizing CD25 to the target cell-effector cell interface.

Gubbels, Jennifer A A; Gadbaw, Brian; Buhtoiarov, Ilia N; Horibata, Sachi; Kapur, Arvinder K; Patel, Dhara; Hank, Jacquelyn A; Gillies, Stephen D; Sondel, Paul M; Patankar, Manish S; Connor, Joseph

Gubbels, Jennifer A A; Gadbaw, Brian; Buhtoiarov, Ilia N; Horibata, Sachi; Kapur, Arvinder K; Patel, Dhara; Hank, Jacquelyn A; Gillies, Stephen D; Sondel, Paul M; Patankar, Manish S; Connor, Joseph.

Affiliation

Gubbels JA; Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI 53711, USA. jennifer.gubbels@augie.edu

Cancer Immunol Immunother ; 60(12): 1789-800, 2011 Dec.

Article in En | MEDLINE | ID: mdl-21792658

Subject(s)

Immunological Synapses/immunology; Immunotherapy/methods; Interleukin-2 Receptor alpha Subunit/immunology; Interleukin-2/analogs & derivatives; Killer Cells, Natural/immunology; Antibodies, Monoclonal; Cell Line, Tumor; Cell Separation; Female; Flow Cytometry; Gangliosides/immunology; Humans; Interleukin-2/immunology; Interleukin-2 Receptor alpha Subunit/metabolism; Lymphocyte Activation/immunology; Microscopy, Confocal; Ovarian Neoplasms/immunology; Protein Transport/immunology; Recombinant Fusion Proteins

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Full text: 1 Database: MEDLINE Main subject: Killer Cells, Natural / Interleukin-2 / Interleukin-2 Receptor alpha Subunit / Immunological Synapses / Immunotherapy Limits: Female / Humans Language: En Journal: Cancer Immunol Immunother Journal subject: ALERGIA E IMUNOLOGIA / NEOPLASIAS / TERAPEUTICA Year: 2011 Type: Article Affiliation country: United States

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