Dual targeting of mTORC1/C2 complexes enhances histone deacetylase inhibitor-mediated anti-tumor efficacy in primary HCC cancer in vitro and in vivo.

Shao, Huanjie; Gao, Chun; Tang, Haikuo; Zhang, Hao; Roberts, Lewis R; Hylander, Bonnie L; Repasky, Elizabeth A; Ma, Wen W; Qiu, Jingxin; Adjei, Alex A; Dy, Grace K; Yu, Chunrong

Shao, Huanjie; Gao, Chun; Tang, Haikuo; Zhang, Hao; Roberts, Lewis R; Hylander, Bonnie L; Repasky, Elizabeth A; Ma, Wen W; Qiu, Jingxin; Adjei, Alex A; Dy, Grace K; Yu, Chunrong.

Affiliation

Shao H; Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

J Hepatol ; 56(1): 176-83, 2012 Jan.

Article in En | MEDLINE | ID: mdl-21835141

Subject(s)

Carcinoma, Hepatocellular/drug therapy; Histone Deacetylase Inhibitors/administration & dosage; Liver Neoplasms/drug therapy; Proteins/antagonists & inhibitors; Transcription Factors/antagonists & inhibitors; Animals; Apoptosis Regulatory Proteins/antagonists & inhibitors; Apoptosis Regulatory Proteins/genetics; Apoptosis Regulatory Proteins/metabolism; Base Sequence; Bcl-2-Like Protein 11; Carcinoma, Hepatocellular/genetics; Carcinoma, Hepatocellular/metabolism; Carcinoma, Hepatocellular/pathology; Cell Death/drug effects; Cell Line, Tumor; Drug Synergism; Female; Gene Knockdown Techniques; Humans; Liver Neoplasms/genetics; Liver Neoplasms/metabolism; Liver Neoplasms/pathology; Mechanistic Target of Rapamycin Complex 1; Membrane Proteins/antagonists & inhibitors; Membrane Proteins/genetics; Membrane Proteins/metabolism; Mice; Mice, SCID; Multiprotein Complexes; Proto-Oncogene Proteins/antagonists & inhibitors; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-akt/antagonists & inhibitors; Proto-Oncogene Proteins c-akt/genetics; Proto-Oncogene Proteins c-akt/metabolism; RNA, Small Interfering/genetics; Signal Transduction/drug effects; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays

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Full text: 1 Database: MEDLINE Main subject: Transcription Factors / Proteins / Carcinoma, Hepatocellular / Histone Deacetylase Inhibitors / Liver Neoplasms Type of study: Prognostic_studies Language: En Journal: J Hepatol Journal subject: GASTROENTEROLOGIA Year: 2012 Type: Article Affiliation country: United States

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