Acidic mammalian chitinase is not a critical target for allergic airway disease.

Fitz, Lori J; DeClercq, Charlene; Brooks, Jonathan; Kuang, Wen; Bates, Brian; Demers, Delia; Winkler, Aaron; Nocka, Karl; Jiao, Aiping; Greco, Rita M; Mason, Lawrence E; Fleming, Margaret; Quazi, Amira; Wright, Jill; Goldman, Samuel; Hubeau, Cedric; Williams, Cara M M

Fitz, Lori J; DeClercq, Charlene; Brooks, Jonathan; Kuang, Wen; Bates, Brian; Demers, Delia; Winkler, Aaron; Nocka, Karl; Jiao, Aiping; Greco, Rita M; Mason, Lawrence E; Fleming, Margaret; Quazi, Amira; Wright, Jill; Goldman, Samuel; Hubeau, Cedric; Williams, Cara M M.

Affiliation

Fitz LJ; Inflammation and Immunology Research Unit, Pfizer, Cambridge, Massachusetts 02140, USA. Lori.Fitz@pfizer.com

Am J Respir Cell Mol Biol ; 46(1): 71-9, 2012 Jan.

Article in En | MEDLINE | ID: mdl-21836154

Subject(s)

Asthma/enzymology; Chitinases/antagonists & inhibitors; Hypersensitivity/enzymology; Allergens/immunology; Animals; Asthma/genetics; Asthma/immunology; Bronchoalveolar Lavage Fluid/immunology; Chitinases/deficiency; Chitinases/genetics; Chitinases/immunology; Female; Humans; Hypersensitivity/genetics; Hypersensitivity/immunology; Inflammation/enzymology; Inflammation/genetics; Inflammation/immunology; Interleukin-13/immunology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neutrophils/immunology; Th1 Cells/immunology; Th2 Cells/immunology

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Full text: 1 Database: MEDLINE Main subject: Asthma / Chitinases / Hypersensitivity Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Am J Respir Cell Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2012 Type: Article Affiliation country: United States

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