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Toward the blood-borne miRNome of human diseases.
Keller, Andreas; Leidinger, Petra; Bauer, Andrea; Elsharawy, Abdou; Haas, Jan; Backes, Christina; Wendschlag, Anke; Giese, Nathalia; Tjaden, Christine; Ott, Katja; Werner, Jens; Hackert, Thilo; Ruprecht, Klemens; Huwer, Hanno; Huebers, Junko; Jacobs, Gunnar; Rosenstiel, Philip; Dommisch, Henrik; Schaefer, Arne; Müller-Quernheim, Joachim; Wullich, Bernd; Keck, Bastian; Graf, Norbert; Reichrath, Joerg; Vogel, Britta; Nebel, Almut; Jager, Sven U; Staehler, Peer; Amarantos, Ioannis; Boisguerin, Valesca; Staehler, Cord; Beier, Markus; Scheffler, Matthias; Büchler, Markus W; Wischhusen, Joerg; Haeusler, Sebastian F M; Dietl, Johannes; Hofmann, Sylvia; Lenhof, Hans-Peter; Schreiber, Stefan; Katus, Hugo A; Rottbauer, Wolfgang; Meder, Benjamin; Hoheisel, Joerg D; Franke, Andre; Meese, Eckart.
Affiliation
  • Keller A; Biomarker Discovery Center, Heidelberg, Germany. ack@bioinf.uni-sb.de
Nat Methods ; 8(10): 841-3, 2011 Sep 04.
Article in En | MEDLINE | ID: mdl-21892151
ABSTRACT
In a multicenter study, we determined the expression profiles of 863 microRNAs by array analysis of 454 blood samples from human individuals with different cancers or noncancer diseases, and validated this 'miRNome' by quantitative real-time PCR. We detected consistently deregulated profiles for all tested diseases; pathway analysis confirmed disease association of the respective microRNAs. We observed significant correlations (P = 0.004) between the genomic location of disease-associated genetic variants and deregulated microRNAs.
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Full text: 1 Database: MEDLINE Main subject: Disease / MicroRNAs Type of study: Clinical_trials Limits: Humans Language: En Journal: Nat Methods Journal subject: TECNICAS E PROCEDIMENTOS DE LABORATORIO Year: 2011 Type: Article Affiliation country: Germany
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Full text: 1 Database: MEDLINE Main subject: Disease / MicroRNAs Type of study: Clinical_trials Limits: Humans Language: En Journal: Nat Methods Journal subject: TECNICAS E PROCEDIMENTOS DE LABORATORIO Year: 2011 Type: Article Affiliation country: Germany