Inhibition of neuronal cholesterol biosynthesis with lovastatin leads to impaired synaptic vesicle release even in the presence of lipoproteins or geranylgeraniol.

Mailman, Tiffany; Hariharan, Manoj; Karten, Barbara

Mailman, Tiffany; Hariharan, Manoj; Karten, Barbara.

Affiliation

Mailman T; Department of Biochemistry and Molecular Biology and Neuroscience Institute, Dalhousie University, Halifax, Nova Scotia, Canada.

J Neurochem ; 119(5): 1002-15, 2011 Dec.

Article in En | MEDLINE | ID: mdl-21899539

Subject(s)

Anticholesteremic Agents/toxicity; Cholesterol/metabolism; Diterpenes/pharmacology; Lipoproteins/physiology; Lovastatin/toxicity; Neurons/metabolism; Synaptic Transmission/physiology; Synaptic Vesicles/metabolism; Animals; Animals, Newborn; Astrocytes/cytology; Astrocytes/drug effects; Astrocytes/metabolism; Cell Line; Cholesterol/biosynthesis; Mice; Neural Inhibition/physiology; Neurons/cytology; Neurons/drug effects; Presynaptic Terminals/drug effects; Presynaptic Terminals/physiology; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Synaptic Transmission/drug effects; Synaptic Vesicles/drug effects

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Synaptic Vesicles / Lovastatin / Cholesterol / Synaptic Transmission / Diterpenes / Lipoproteins / Anticholesteremic Agents / Neurons Limits: Animals Language: En Journal: J Neurochem Year: 2011 Type: Article Affiliation country: Canada

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google