Selective inhibitors of histone methyltransferase DOT1L: design, synthesis, and crystallographic studies.

Yao, Yuan; Chen, Pinhong; Diao, Jiasheng; Cheng, Gang; Deng, Lisheng; Anglin, Justin L; Prasad, B V Venkataram; Song, Yongcheng

Yao, Yuan; Chen, Pinhong; Diao, Jiasheng; Cheng, Gang; Deng, Lisheng; Anglin, Justin L; Prasad, B V Venkataram; Song, Yongcheng.

Affiliation

Yao Y; Department of Pharmacology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.

J Am Chem Soc ; 133(42): 16746-9, 2011 Oct 26.

Article in En | MEDLINE | ID: mdl-21936531

Subject(s)

Enzyme Inhibitors/chemistry; Enzyme Inhibitors/chemical synthesis; Methyltransferases/antagonists & inhibitors; Crystallography, X-Ray; Histone-Lysine N-Methyltransferase; Humans; Inhibitory Concentration 50; Molecular Structure

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Full text: 1 Database: MEDLINE Main subject: Enzyme Inhibitors / Methyltransferases Limits: Humans Language: En Journal: J Am Chem Soc Year: 2011 Type: Article Affiliation country: United States

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