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Structure-guided inhibitor design for human acetyl-coenzyme A carboxylase by interspecies active site conversion.
Rajamohan, Francis; Marr, Eric; Reyes, Allan R; Landro, James A; Anderson, Marie D; Corbett, Jeffrey W; Dirico, Kenneth J; Harwood, James H; Tu, Meihua; Vajdos, Felix F.
Affiliation
  • Rajamohan F; Pfizer Global Research and Development, Groton, Connecticut 06340. Electronic address: francis.rajamohan@pfizer.com.
  • Marr E; Pfizer Global Research and Development, Groton, Connecticut 06340.
  • Reyes AR; Pfizer Global Research and Development, Groton, Connecticut 06340.
  • Landro JA; Pfizer Global Research and Development, Groton, Connecticut 06340.
  • Anderson MD; Pfizer Global Research and Development, Groton, Connecticut 06340.
  • Corbett JW; Pfizer Global Research and Development, Groton, Connecticut 06340.
  • Dirico KJ; Pfizer Global Research and Development, Groton, Connecticut 06340.
  • Harwood JH; Pfizer Global Research and Development, Groton, Connecticut 06340.
  • Tu M; Pfizer Global Research and Development, Groton, Connecticut 06340.
  • Vajdos FF; Pfizer Global Research and Development, Groton, Connecticut 06340. Electronic address: felix.vajdos@pfizer.com.
J Biol Chem ; 286(48): 41510-41519, 2011 Dec 02.
Article in En | MEDLINE | ID: mdl-21953464
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Full text: 1 Database: MEDLINE Main subject: Acetyl-CoA Carboxylase / Catalytic Domain / Saccharomyces cerevisiae Proteins / Enzyme Inhibitors Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2011 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Acetyl-CoA Carboxylase / Catalytic Domain / Saccharomyces cerevisiae Proteins / Enzyme Inhibitors Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2011 Type: Article