A common 5'-UTR variant in MATE2-K is associated with poor response to metformin.

Choi, J H; Yee, S W; Ramirez, A H; Morrissey, K M; Jang, G H; Joski, P J; Mefford, J A; Hesselson, S E; Schlessinger, A; Jenkins, G; Castro, R A; Johns, S J; Stryke, D; Sali, A; Ferrin, T E; Witte, J S; Kwok, P-Y; Roden, D M; Wilke, R A; McCarty, C A; Davis, R L; Giacomini, K M

Choi, J H; Yee, S W; Ramirez, A H; Morrissey, K M; Jang, G H; Joski, P J; Mefford, J A; Hesselson, S E; Schlessinger, A; Jenkins, G; Castro, R A; Johns, S J; Stryke, D; Sali, A; Ferrin, T E; Witte, J S; Kwok, P-Y; Roden, D M; Wilke, R A; McCarty, C A; Davis, R L; Giacomini, K M.

Affiliation

Choi JH; Department of Pharmacology, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, Korea.

Clin Pharmacol Ther ; 90(5): 674-84, 2011 Nov.

Article in En | MEDLINE | ID: mdl-21956618

Subject(s)

Diabetes Mellitus, Type 2/drug therapy; Hypoglycemic Agents/pharmacokinetics; Metformin/pharmacokinetics; Organic Cation Transport Proteins/genetics; Adult; Aged; Alleles; Animals; Female; Genetic Variation; Glycated Hemoglobin/metabolism; HCT116 Cells; HEK293 Cells; Haplotypes; Humans; Hypoglycemic Agents/pharmacology; LLC-PK1 Cells; Luciferases/metabolism; Male; Metformin/pharmacology; Middle Aged; Polymorphism, Genetic; Promoter Regions, Genetic; Racial Groups/genetics; Retrospective Studies; Swine; Treatment Outcome

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Full text: 1 Database: MEDLINE Main subject: Organic Cation Transport Proteins / Diabetes Mellitus, Type 2 / Hypoglycemic Agents / Metformin Type of study: Observational_studies / Risk_factors_studies Limits: Adult / Aged / Animals / Female / Humans / Male / Middle aged Language: En Journal: Clin Pharmacol Ther Year: 2011 Type: Article

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