Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients.

Hu, Guanggan; Wang, Joyce; Choi, Jaehyuk; Jung, Won Hee; Liu, Iris; Litvintseva, Anastasia P; Bicanic, Tihana; Aurora, Rajeev; Mitchell, Thomas G; Perfect, John R; Kronstad, James W

Hu, Guanggan; Wang, Joyce; Choi, Jaehyuk; Jung, Won Hee; Liu, Iris; Litvintseva, Anastasia P; Bicanic, Tihana; Aurora, Rajeev; Mitchell, Thomas G; Perfect, John R; Kronstad, James W.

Affiliation

Hu G; The Michael Smith Laboratories, Department of Microbiology and Immunology, and Faculty of Land and Food Systems, University of British Columbia, Vancouver, B.C. V6T 1Z4, Canada.

BMC Genomics ; 12: 526, 2011 Oct 27.

Article in En | MEDLINE | ID: mdl-22032296

Subject(s)

AIDS-Related Opportunistic Infections/microbiology; Chromosomes, Fungal/genetics; Cryptococcus neoformans/genetics; DNA Copy Number Variations; AIDS-Related Opportunistic Infections/cerebrospinal fluid; Animals; Comparative Genomic Hybridization; Cryptococcosis/microbiology; Cryptococcus neoformans/isolation & purification; Cryptococcus neoformans/pathogenicity; Female; Humans; Melanins/biosynthesis; Mice; Mice, Inbred BALB C; Virulence; Virulence Factors/genetics

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Full text: 1 Database: MEDLINE Main subject: Chromosomes, Fungal / AIDS-Related Opportunistic Infections / Cryptococcus neoformans / DNA Copy Number Variations Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: BMC Genomics Journal subject: GENETICA Year: 2011 Type: Article Affiliation country: Canada

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