Register shifting of an insulin peptide-MHC complex allows diabetogenic T cells to escape thymic deletion.

Mohan, James F; Petzold, Shirley J; Unanue, Emil R

Mohan, James F; Petzold, Shirley J; Unanue, Emil R.

Affiliation

Mohan JF; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.

J Exp Med ; 208(12): 2375-83, 2011 Nov 21.

Article in En | MEDLINE | ID: mdl-22065673

Subject(s)

Autoimmunity/immunology; CD4-Positive T-Lymphocytes/cytology; Diabetes Mellitus, Type 1/immunology; Insulin/immunology; Islets of Langerhans/immunology; Major Histocompatibility Complex/immunology; Amino Acid Substitution; Animals; Cell Line; DNA Primers/genetics; Enzyme-Linked Immunospot Assay; Insulin/genetics; Insulin/metabolism; Mice; Mice, Inbred NOD; Protein Binding; T-Cell Antigen Receptor Specificity; Thymus Gland/immunology

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Full text: 1 Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / Autoimmunity / Islets of Langerhans / Diabetes Mellitus, Type 1 / Insulin / Major Histocompatibility Complex Limits: Animals Language: En Journal: J Exp Med Year: 2011 Type: Article Affiliation country: United States

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