Altered REDD1, myostatin, and Akt/mTOR/FoxO/MAPK signaling in streptozotocin-induced diabetic muscle atrophy.

Hulmi, Juha J; Silvennoinen, Mika; Lehti, Maarit; Kivelä, Riikka; Kainulainen, Heikki

Hulmi, Juha J; Silvennoinen, Mika; Lehti, Maarit; Kivelä, Riikka; Kainulainen, Heikki.

Affiliation

Hulmi JJ; Department of Biology of Physical Activity, Neuromuscular Research Center, University of Jyväskylä, Jyväskylä, Finland. juha.hulmi@jyu.fi

Am J Physiol Endocrinol Metab ; 302(3): E307-15, 2012 Feb 01.

Article in En | MEDLINE | ID: mdl-22068602

Subject(s)

Diabetes Mellitus, Type 1/complications; MAP Kinase Signaling System; Muscle, Skeletal/metabolism; Muscular Atrophy/complications; Muscular Atrophy/metabolism; Myostatin/metabolism; Transcription Factors/metabolism; Animals; DNA Repair Enzymes/genetics; DNA Repair Enzymes/metabolism; Forkhead Box Protein O1; Forkhead Transcription Factors/metabolism; Gene Expression Profiling; Gene Expression Regulation; Male; Mice; Muscle, Skeletal/pathology; Muscular Atrophy/pathology; Oligonucleotide Array Sequence Analysis; Organ Size; Phosphorylation; Proto-Oncogene Proteins c-akt/metabolism; RNA, Messenger/metabolism; Random Allocation; TOR Serine-Threonine Kinases/metabolism; Transcription Factors/genetics; Ubiquitination

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Full text: 1 Database: MEDLINE Main subject: Transcription Factors / Muscular Atrophy / Muscle, Skeletal / MAP Kinase Signaling System / Diabetes Mellitus, Type 1 / Myostatin Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Physiol Endocrinol Metab Journal subject: ENDOCRINOLOGIA / FISIOLOGIA / METABOLISMO Year: 2012 Type: Article Affiliation country: Finland

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