A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase.

Jiang, Jiaoyang; Lazarus, Michael B; Pasquina, Lincoln; Sliz, Piotr; Walker, Suzanne

Jiang, Jiaoyang; Lazarus, Michael B; Pasquina, Lincoln; Sliz, Piotr; Walker, Suzanne.

Affiliation

Jiang J; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.

Nat Chem Biol ; 8(1): 72-7, 2011 Nov 13.

Article in En | MEDLINE | ID: mdl-22082911

Subject(s)

Biomimetic Materials/metabolism; Catalytic Domain; Diphosphates/metabolism; N-Acetylglucosaminyltransferases/metabolism; Benzoxazoles/chemistry; Benzoxazoles/pharmacology; Biomimetic Materials/chemistry; Crystallography, X-Ray; Diphosphates/chemistry; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/pharmacology; Humans; Models, Molecular; N-Acetylglucosaminyltransferases/antagonists & inhibitors

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Full text: 1 Database: MEDLINE Main subject: N-Acetylglucosaminyltransferases / Diphosphates / Catalytic Domain / Biomimetic Materials Limits: Humans Language: En Journal: Nat Chem Biol Journal subject: BIOLOGIA / QUIMICA Year: 2011 Type: Article Affiliation country: United States

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