Generation and functional characterization of knock-in mice harboring the cardiac troponin I-R21C mutation associated with hypertrophic cardiomyopathy.

Wang, Yingcai; Pinto, Jose Renato; Solis, Raquel Sancho; Dweck, David; Liang, Jingsheng; Diaz-Perez, Zoraida; Ge, Ying; Walker, Jeffery W; Potter, James D

Wang, Yingcai; Pinto, Jose Renato; Solis, Raquel Sancho; Dweck, David; Liang, Jingsheng; Diaz-Perez, Zoraida; Ge, Ying; Walker, Jeffery W; Potter, James D.

Affiliation

Wang Y; Department of Molecular and Cellular Pharmacology, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA.

J Biol Chem ; 287(3): 2156-67, 2012 Jan 13.

Article in En | MEDLINE | ID: mdl-22086914

Subject(s)

Amino Acid Substitution; Cardiomyopathy, Hypertrophic, Familial/metabolism; Mutation, Missense; Myocardium/metabolism; Myofibrils/metabolism; Troponin I/metabolism; Animals; Anti-Arrhythmia Agents/pharmacology; Calcium/metabolism; Cardiomyopathy, Hypertrophic, Familial/genetics; Cardiomyopathy, Hypertrophic, Familial/pathology; Cyclic AMP-Dependent Protein Kinases/genetics; Cyclic AMP-Dependent Protein Kinases/metabolism; Endomyocardial Fibrosis/genetics; Endomyocardial Fibrosis/metabolism; Gene Knock-In Techniques; Humans; Mice; Mice, Mutant Strains; Myocardium/pathology; Myofibrils/genetics; Myofibrils/pathology; Phosphorylation/genetics; Propranolol/pharmacology; Troponin I/genetics

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Troponin I / Amino Acid Substitution / Mutation, Missense / Cardiomyopathy, Hypertrophic, Familial / Myocardium / Myofibrils Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2012 Type: Article Affiliation country: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google