Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator-activated receptor Î³ in hepatic stellate cells for their antifibrotic effect.

Yang, Melissa D; Chiang, Yi-Ming; Higashiyama, Reiichi; Asahina, Kinji; Mann, Derek A; Mann, Jelena; Wang, Clay C C; Tsukamoto, Hidekazu

Yang, Melissa D; Chiang, Yi-Ming; Higashiyama, Reiichi; Asahina, Kinji; Mann, Derek A; Mann, Jelena; Wang, Clay C C; Tsukamoto, Hidekazu.

Affiliation

Yang MD; Southern California Research Center for ALPD and Cirrhosis and Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Hepatology ; 55(4): 1271-81, 2012 Apr.

Article in En | MEDLINE | ID: mdl-22095555

Subject(s)

Cinnamates/pharmacology; Depsides/pharmacology; Epigenesis, Genetic/physiology; Flavonoids/pharmacology; Hepatic Stellate Cells/drug effects; Hepatic Stellate Cells/metabolism; Liver Cirrhosis/pathology; PPAR gamma/metabolism; Animals; Cell Differentiation/drug effects; Cells, Cultured; Cinnamates/therapeutic use; Depsides/therapeutic use; Disease Models, Animal; Drugs, Chinese Herbal/pharmacology; Drugs, Chinese Herbal/therapeutic use; Gene Expression Regulation/drug effects; Hepatic Stellate Cells/pathology; Liver Cirrhosis/drug therapy; Liver Cirrhosis/prevention & control; Male; Mice; Mice, Inbred C57BL; NF-kappa B/metabolism; PPAR gamma/genetics; Rats; Rats, Wistar; Signal Transduction/drug effects; Signal Transduction/physiology; Wnt Proteins/genetics; Wnt Proteins/metabolism; Rosmarinic Acid

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Full text: 1 Database: MEDLINE Main subject: Flavonoids / Cinnamates / Epigenesis, Genetic / PPAR gamma / Depsides / Hepatic Stellate Cells / Liver Cirrhosis Type of study: Prognostic_studies Limits: Animals Language: En Journal: Hepatology Year: 2012 Type: Article Affiliation country: United States

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